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Although epiploic appendagitis has not been identified as an adverse event or safety signal in randomized trials, systematic reviews, or pharmacovigilance analyses of GLP-1/GIP receptor agonists, it is biologically plausible that rapid weight loss could increase susceptibility to this condition

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Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism

It appears to: improve blood flow by improving the utilization of fatty acids for energy, which can help reduce muscle fatigue, increase oxygen supply to the affected limbs, and improve walking capacity reduce symptoms, such as leg pain (claudication), and improve the walking distance before the onset of pain